July 26th, 2012 by Len Saunders
From The Los Angeles Times?..
Remember the experimental weight-loss drug rimonabant, touted as a potential ?miracle pill? that could help obese smokers kick the habit, lose weight and keep it off for two years? Marketed in Europe as Acomplia, the drug made it well into the U.S. Food and Drug Administration?s approval process before it was linked in 2008 to a doubling of depression risk in those taking it. The drug ended up withdrawn from the European market and pulled from FDA consideration, another failed medication on the ash heap of obesity treatments.
Or maybe not. A new study finds that a structural modification that prevents the active molecule from entering the brain might give a new lease on life to the the whole idea of promoting weight loss by manipulating the body?s cannibinoid-receptor system.
In a study published in the journal Cell Metabolism, scientists gave obese rats a chemical variant of the drug that gave rimonabant its ability to bring about weight loss. The resulting agent, called JD5037, ?robustly reduces food intake, body weight and adiposity? and was ?devoid of behavioral effects,? the researchers reported.
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Entry Filed under: Health / Fitness Articles
Source: http://www.lensaunders.com/wp/?p=2465
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